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Web Karyotyping Activity Essay

This activity gave an insight to the basis of genetic diseases involving chromosomal errors. It is indeed a revolution of diagnostics; the activity also gave insight into the genomic architecture of basic cells thus giving man insight to some basic principles underlying some diseases such as the deletion and addition of some chromosomes as well as some translocations which occur in certain genetic diseases. Although some work still has to be done such as magnifications of the karyotype, and technology to enable one to view the constituent genes that make up the chromosomes as most diseases occur at this level.

Did you find the activity interesting? Yes, the activity was interesting, diagnosing diseases that could only be done by delving into human chromosome by sheer brilliance and keen eyes to match dark and light bands. In the end placing your hands on the problem was exhilarating. What did you learn? There was indeed much to learn, 1. There are 23 pairs of chromosome with one pair as the sex chromosomes 2. The cells are arrested in during mitosis and are stained with Giemsa dye. 3. Karyotype analyses are performed over 400,000 times in the U. S and Canada. 4.

The dye stains

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regions that are rich in Adenine (A) and Thymine (T) as dark bands. 5. The size of one small band is about equal to the size of an entire bacteria genome. 6. A single band contains millions of base pairs and as such, possibly hundred of genes. 7. Down syndrome is caused by an extra chromosome 21 and has the notation: 47,XX,+21. 8. Klinefelter’s syndrome is caused by an extra X chromosome and can cause male infertility. It has the chromosomal notation 47,XXY. 9. An extra chromosome 13 also called Patau Syndrome can cause polydactyl, cleft lip and neonatal death. The chromosomal notation is 47,XX,+13.

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